Minimum Number: 20 Records Kept Since: 1923
| # | Player | Class | Game | Opponent | Points |
|---|---|---|---|---|---|
| 1 | Mike Casey | So. | 12/2/1967 | Michigan | 28 |
| 2 | Tyrese Maxey | Fr. | 11/5/2019 | Michigan State | 26 |
| 3 | Cotton Nash | So. | 12/2/1961 | Miami (OH) | 25 |
| 3 | Terrence Jones | Fr. | 11/12/2010 | East Tennessee State | 25 |
| 5 | Eric Bledsoe | Fr. | 11/13/2009 | Morehead | 24 |
| 6 | Anthony Davis | Fr. | 11/11/2011 | Marist | 23 |
| 6 | Julius Randle | Fr. | 11/8/2013 | UNC-Asheville | 23 |
| 6 | Keldon Johnson | Fr. | 11/6/2018 | Duke | 23 |
| 9 | Irvine Jeffries | So. | 1/28/1928 | Tennessee | 22 |
| 9 | Sam Bowie | Fr. | 11/17/1979 | Duke | 22 |
| 9 | Reid Travis | Grad | 11/6/2018 | Duke | 22 |
| 9 | Antonio Reeves | Sr. | 11/7/2022 | Howard | 22 |
| 13 | Brandon Knight | Fr. | 11/19/2010 | Portland | 21 |
| 13 | Otega Oweh | Jr. | 11/4/2024 | Wright State | 21 |
| 15 | Roger Newman | Sr. | 12/1/1960 | Virginia Military | 20 |
| 15 | Doron Lamb | Fr. | 11/12/2010 | East Tennessee State | 20 |
| 15 | C.J. Fredrick | Sr. | 11/7/2022 | Howard | 20 |
